Journal article
Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes
MS DeRycke, S Gunawardena, JR Balcom, AM Pickart, LA Waltman, AJ French, S McDonnell, SM Riska, ZC Fogarty, MC Larson, S Middha, BW Eckloff, YW Asmann, MJ Ferber, RW Haile, S Gallinger, M Clendenning, C Rosty, AK Win, DD Buchanan Show all
Molecular Genetics and Genomic Medicine | WILEY | Published : 2017
DOI: 10.1002/mgg3.317
Abstract
Background: Mutations in several genes predispose to colorectal cancer. Genetic testing for hereditary colorectal cancer syndromes was previously limited to single gene tests; thus, only a very limited number of genes were tested, and rarely those infrequently mutated in colorectal cancer. Next-generation sequencing technologies have made it possible to sequencing panels of genes known and suspected to influence colorectal cancer susceptibility. Methods: Targeted sequencing of 36 known or putative CRC susceptibility genes was conducted for 1231 CRC cases from five subsets: (1) Familial Colorectal Cancer Type X (n = 153); (2) CRC unselected by tumor immunohistochemical or microsatellite stabi..
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Awarded by Foundation for the National Institutes of Health
Funding Acknowledgements
National Cancer Institute (Grant/Award Number: 'CA074778', 'CA074783', 'CA074794', 'CA074799', 'CA074800', 'CA074806', 'CA097735', 'CA104132', 'CA167551', 'HHSN2612013000121', 'N01-CN-67009', 'N01-PC-35142'), Hawai'i Department of Health (Grant/Award Number: 'HHSN26120100037C', 'N01-PC-35137', 'N01-PC-67001'), and California Department of Public Health (Grant/Award Number: 'HHSN261201000035C', 'HHSN261201000140C').